Epiloia (tuberous sclerosis): a report of a case with unusual tumours.

Apart from adenoma sebaceum, involvement of the skin and subcutaneous tissues is a well-known finding in cases of epiloia or tuberous sclerosis. A variety of manifestations occurs, the most frequently noted ones including adenoma sebaceum itself, shagreen plaques, subungual and other small fibromata, cafe-au-lait spots, and areas of depigmented skin. A comprehensive review of the dermatological aspects of the disease was published by Butterworth and Wilson (1941) who summarized the many abnormalities that had been observed. We recently saw a child in Cell Barnes hospital who, in addition to the typical clinical features of epiloia (in particular, epilepsy, mental defect, and adenoma sebaceum), developed superficial tumours which are sufficiently unusual to seem worth while reporting. The following is an account of this patient.